VDR Gene

Vitamin D Receptor - Vitamin D Absorption and Utilization

Overview

The VDR (Vitamin D Receptor) gene encodes the receptor protein that binds to vitamin D and mediates its biological effects. VDR variants can affect how efficiently your body responds to vitamin D, influencing absorption, calcium metabolism, immune function, and gene expression.

Genetic variants in VDR can impact vitamin D receptor sensitivity, potentially requiring higher vitamin D doses or different forms to achieve optimal levels. Understanding your VDR genotype helps personalize your vitamin D supplementation strategy.

Common Variants

Reduced Receptor Sensitivity

High Impact

Receptor Function: Reduced sensitivity to vitamin D

Clinical Significance: Individuals with reduced VDR sensitivity may require higher vitamin D doses to achieve optimal serum levels and biological effects. This can impact bone health, immune function, and overall wellness.

Supplementation Recommendations

Supplement Form:

• Vitamin D3 (Cholecalciferol) - Preferred form, more bioavailable
• Vitamin D2 (Ergocalciferol) - Alternative form, less potent
• Consider liquid or sublingual forms for better absorption

Recommended Dosage:

• Daily Maintenance: 3,000-5,000 IU (may need higher doses)
• Therapeutic: 5,000-10,000 IU daily (under medical supervision)
• Loading Dose: May require initial higher doses to reach optimal levels
• Regular monitoring of 25(OH)D levels is recommended

Synergistic Nutrients:

• Magnesium - Essential for vitamin D activation
• Calcium - Works with vitamin D for bone health
• Vitamin K2 - Directs calcium to bones, away from arteries
• Zinc - Supports immune function alongside vitamin D

Timing Considerations:

• Take with a meal containing healthy fats for optimal absorption
• Morning dosing may be preferable for some individuals
• Consider splitting doses if taking very high amounts

Normal Receptor Sensitivity

Normal Function

Receptor Function: Normal sensitivity to vitamin D

Clinical Significance: Normal response to vitamin D. Standard supplementation guidelines (1,000-2,000 IU daily) are typically sufficient, though individual needs may vary based on sun exposure, diet, and health status.

Research Evidence

Genetic Studies: VDR polymorphisms have been associated with variations in vitamin D response, bone mineral density, and immune function.

Clinical Applications: VDR genotyping is increasingly used to personalize vitamin D supplementation, particularly for individuals who don't respond well to standard doses.

Population Studies: VDR variants show different frequencies across populations, which may contribute to differences in vitamin D requirements and deficiency rates.

Important Considerations

• Regular monitoring of 25(OH)D levels is essential, especially with higher doses
• Target levels: 40-60 ng/mL (100-150 nmol/L) for optimal health
• Vitamin D toxicity is rare but possible with very high doses over extended periods
• Consider co-supplementation with magnesium and K2 for optimal benefits
• Individual response can vary based on multiple factors beyond genetics